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NEWS & MEDIA / BREEDING BACKED BY SCIENCE WITH ETALON EQUINE GENETICS: LEVERAGING GENETIC TESTING TO MAXIMIZE PERFORMANCE, EVALUATE HEALTH RISKS VS. CONDITIONS, AND AVOID FOAL FATALITIES

Breeding Backed by Science with Etalon Equine Genetics: Leveraging Genetic Testing to Maximize Performance, Evaluate Health Risks vs. Conditions, and Avoid Foal Fatalities

March 14, 2024

How cool would it be to build your perfect horse down to their DNA? With Etalon Equine Genetics, the odds can be tipped in your favor! Welcome to the world of equine breeding, where every decision you make plays a crucial role in shaping the future generation of horses. Breeding horses is not only an art but a science. With advancements in genetic testing, breeders now have powerful tools at their disposal to make informed decisions like never before.

Whether you are a seasoned professional or new to the world of breeding, understanding the importance of genetic testing and its implications for producing healthy foals is fundamental. Join us to explore how Etalon Equine Genetics can revolutionize your breeding program by offering and applying comprehensive genetic testing solutions that go beyond the standard DNA panels required by breed associations.

The Importance of Genetic Testing

DNA testing has emerged as a cornerstone of modern breeding practices, providing valuable insights into the genomic makeup of individual horses. While we are not advocating for tossing traditional pedigree analysis and physical evaluations out the window, genetic testing offers a deeper and more accurate understanding of each horse's genetic predispositions, including potential health risks and hereditary traits. Etalon Equine Genetics is leading the field of genetic testing by offering advanced testing that covers an extensive array of genetic variants, providing breeders with a truly comprehensive overview of their horses' genetic profiles. In today's increasingly competitive breeding landscape, where the demand for top-quality performance and conformation in horses is ever-present, genetic testing and analysis have become an indispensable tool for breeders striving to achieve excellence in their programs.

So why exactly is genetic testing a crucial element of breeding and owning horses?

Selective Breeding: By understanding the genetic makeup of potential breeding pairs, breeders can strategically select stallions and mares that complement each other's strengths and weaknesses, ultimately improving the overall quality of the foals they produce.

Promoting Health, Preventing Disease: Genetic testing helps identify potential health risks and conditions, allowing breeders to make informed decisions to mitigate these risks. It can also identify carriers of hereditary diseases, enabling breeders to avoid mating carriers with other carriers or affected horses, thereby reducing the risk of producing foals with inherited disorders, including some that are known to be fatal.

Optimizing Traits: Breeders can leverage the results of genetic testing to identify desirable traits and characteristics, such as coat color and performance abilities, allowing them to selectively breed for these traits.

Long-term Sustainability: By prioritizing genetic health and diversity, breeders contribute to the long-term sustainability of equine populations, ensuring that future generations of horses remain healthy and resilient.

While breeding for phenotype (traits that can be observed such as color and conformation) has been common practice for millennia, DNA testing opens up a new door that allows us to breed animals for their genotype (the actual genetic makeup of an individual). Breeders who prioritize genetic testing recognize its potential to optimize breeding decisions, mitigate the risk of hereditary diseases, and enhance the overall quality of their breeding program. By working with reputable genetic testing providers such as Etalon Equine Genetics, breeders gain access to advanced technologies and comprehensive testing panels that go beyond the standard requirements of breed associations. Etalon's testing services cover a wide range of genetic markers, including those associated with coat color and pattern, performance traits, and hereditary health conditions, empowering breeders to make informed decisions based on a thorough understanding of their horses' unique genetic makeup.

The decision to invest in genetic testing reflects a commitment to responsible breeding practices and the welfare of future generations of horses. By leveraging the insights provided by genetic testing, breeders can optimize their breeding pairings, identify and manage (or even eliminate) the possibility of potential health risks, and preserve desirable traits within their breeding programs. Moreover, genetic testing enables breeders to uphold standards of transparency and accountability within the equine industry, providing buyers with confidence in the health and genetic integrity of the horses they acquire.

A paint horse stallion is shown with an "Etalon Verified" ribbon

When you see that a horse is “Etalon Verified,” you can rest assured that the horse in front of you has been genetically tested to ISAG standards by Etalon. While all of our comprehensive DNA panels go above and beyond traditional panels to evaluate a horse for a wide range of color, health, and performance traits that all come into play when evaluating their potential as breeding stock, our signature ProPanel is our most complete health and performance package, testing a horse for more than 75 genetic traits. Compare all of our most popular panels here!

Genetic testing represents a paradigm shift in equine breeding, enabling breeders to harness the power of science to achieve their breeding goals. As the adoption of genetic testing continues to grow within the equine community, breeders who embrace this technology stand poised to lead the way in producing horses of exceptional quality, health, and performance. By choosing Etalon, breeders gain access to cutting-edge technology that can identify a wide range of genetic traits, from coat color and pattern to performance-enhancing genes and hereditary health conditions. This wealth of information empowers breeders to make more informed decisions when selecting breeding pairs, ensuring that each mating is strategically planned to optimize desired traits and minimize the risk of hereditary diseases.

Understanding Health Risks vs. Health Conditions

It is essential that all equine enthusiasts, breeder or not, understand the distinction between health risks and health conditions when interpreting genetic test results. Both terms are integral to understanding a horse's genetic profile, but they carry different implications for the horse's health and welfare. While a health risk indicates the potential for a certain trait or condition to manifest, it does not guarantee that the horse will develop the condition. On the other hand, a health condition suggests the presence of a specific genetic mutation associated with a particular disease or disorder. There are also some instances where a horse is a ‘carrier’ of a gene that cannot be seen but can be detrimental, even lethal, for a foal if that horse is bred to another carrier.

To understand a horse’s genotype for any particular health risk or condition, it’s crucial to understand the terms heterozygous, homozygous, dominant, and recessive in terms of genetics. For the sake of ease, we will use base coat color, known as Extension (E), as an example to explain these foundational terms.

When your horse inherits two identical alleles from their parents, one from the sire and one from the dam, the resulting combined gene is homozygous (as in “homozygous black” or E/E). If two different alleles are inherited, the gene is heterozygous (as in “heterozygous black” or E/e). These combinations of alleles determine our unique genotypes. In the case of certain color and performance genetics, these alleles also influence phenotype. As mentioned before, a genotype is what an individual has for genes, and a phenotype is what we can observe or what is expressed such as their appearance, development, and behavior.

Dominant alleles will produce that particular phenotype regardless of whether they are heterozygous or homozygous for that gene, hence the term dominant! In the case of Extension, the allele for Black “E” would be dominant and expressed over Red “e” (which is recessive). A single dominant allele can come from just one parent. For a recessive phenotype to occur, a red base coat for example, the individual would need to inherit two copies of the recessive allele, one from each parent. Because your horse inherits two alleles, their results will read as “allele 1/allele 2”, as in “e/e” or “ee”.

An infographic compares the differences and similarities between a health risk and a health condition in terms of DNA testing with Etalon Equine Genetics.

Health Risks

A health risk, as identified through genetic testing, denotes the potential for a certain trait or condition to manifest in the horse's lifetime. This could include predispositions to specific diseases, such as recurrent laryngeal neuropathy (commonly called roaring) or kissing spines, or traits associated with increased susceptibility to certain environmental factors, such as equine recurrent uveitis, laminitis, and chronic idiopathic anhidrosis. Health risks typically increase if a horse is homozygous at that specific gene, compared to if they are heterozygous. Importantly, a health risk does not guarantee that the horse will develop the associated condition but rather serves as a cautionary indication for owners to take preventative management measures and for breeders to consider when making breeding decisions.

Health Conditions

On the other hand, a health condition identified through genetic testing signifies the presence of a specific genetic mutation associated with a particular disease or disorder. Unlike a health risk, which may only increase the likelihood of developing a condition, a health condition indicates a definitive genetic predisposition that may necessitate proactive management strategies or selective breeding practices. Examples of commonly known and tested health conditions include genetic disorders such as hyperkalemic periodic paralysis (HYPP) and hereditary equine regional dermal asthenia (HERDA). Other lesser-known health conditions that are often overlooked in standard testing but should be considered when breeding include fragile foal syndrome (formerly known as warmblood fragile foal syndrome) and hydrocephalus.

Understanding whether a horse, both mare and stallion, is a carrier of health risks or conditions is key to responsible breeding practices. In many circumstances, health conditions are autosomal recessive disorders, meaning horses must inherit two copies of the affected allele to develop the disease. Horses with only one affected allele are known as carriers due to their ability to produce affected offspring. While carriers themselves may not exhibit clinical symptoms of the condition, when bred to another carrier, they can create a foal with a potentially fatal disease.

This also does not apply solely to health conditions; certain color genes can be deadly when a foal inherits two copies of them such as lethal white overo (LWO), which has been selectively bred for in some instances to produce horses with frame overo colored coats. By identifying carriers through genetic testing, breeders can make informed decisions to avoid mating carriers with other carriers or affected horses, thereby reducing the likelihood of producing foals with inherited disorders. Additionally, knowledge of carrier status enables breeders to implement targeted breeding strategies, such as outcrossing or selecting mates with complementary genetic profiles, to minimize or even eliminate the transmission of potentially harmful traits and promote the advancement of desirable ones.

Etalon Equine Genetics provides clear and detailed reports that empower breeders to understand and act upon these health risks and conditions effectively. By identifying potential health risks early on, owners and breeders can implement targeted management strategies to minimize the likelihood of the associated disease from manifesting in their horses. By pinpointing a horse’s health conditions from their DNA, breeders have the opportunity to lessen the chances that their future foals will carry those conditions in the first place. Whether it be a health risk or a condition, genetic testing is the first step in preventatively or proactively managing a horse’s health, effectively safeguarding the well-being of future generations of horses, and ensuring the legacy of breeding programs.

Preventing Foal Fatalities

Foal fatalities represent one of the most heartbreaking outcomes in equine breeding, often resulting from the inheritance of lethal homozygous traits. These traits, when present in both parents, can lead to the birth of foals with severe genetic abnormalities incompatible with life. Common examples include disorders such as lethal white syndrome, where the foal is born white with blue eyes and non-functioning intestines, or conditions like hydrocephalus, which can cause neurological deficits and ultimately prove fatal.

Identifying and mitigating the risk of lethal homozygous recessive traits is paramount for responsible breeders committed to the welfare of their horses. This is where genetic testing with Etalon Equine Genetics plays a pivotal role. By thoroughly analyzing the genetic profiles of potential breeding pairs, Etalon can flag the potential presence of homozygous mutations that would pose a risk to foal health. Armed with this knowledge, breeders can make informed decisions to avoid pairings that carry such risks, thus preventing the tragedy of foal fatalities before they occur.

A Punnett square illustrates the potential genetic foal outcomes of breeding two Fragile Foal Syndrome carriers.

Genetic testing allows breeders to proactively address potential health risks and minimize the likelihood of adverse outcomes. By selecting breeding pairs with compatible genetic profiles and strategically avoiding combinations that increase the risk of homozygous disorders, breeders can significantly reduce the incidence of foal fatalities and promote the birth of healthy, thriving foals.

The ability to safeguard foal health through genetic testing not only protects individual animals but also contributes to the long-term sustainability of equine breeding programs. By prioritizing the well-being of future generations and upholding standards of ethical breeding practices, breeders can cultivate a reputation for excellence and integrity within the equine community.

In essence, the prevention of foal fatalities is not merely a matter of chance but a proactive commitment to responsible breeding practices. With Etalon Equine Genetics as a trusted partner, breeders can confidently navigate the complexities of genetic inheritance, ensuring that each foal enters the world with the best possible chance of a healthy and fulfilling life.

Unlocking Breeding Potential with Build-A-Horse

Imagine having your own equine breeding crystal ball—guiding you through the maze of genetic possibilities with ease and precision. That is the magic of Etalon's Build-A-Horse! This innovative tool is not just about crunching numbers (and letters!); it is designed to help you unleash the art of breeding and the power of science to craft the perfect pairing for your next foal. Whether you are dreaming of a future champion in the show ring or a trusty trail companion, Build-A-Horse helps you navigate the genetic landscape to bring your vision to life.

An animation demonstrates how Etalon Equine Genetics' Build-A-Horse tool works.

Build-A-Horse streamlines the breeding process by analyzing the genetic profiles of your potential parent horses and painting a vivid picture of what their offspring might look like. From predicting coat color and pattern to performance traits and health risks, Build-A-Horse offers a comprehensive assessment of genetic potential, empowering breeders to make informed and strategic decisions to improve the welfare of future foals.

But here is the best part — Build-A-Horse is not just for professional breeders with years of experience under their belts. Whether you are just starting out or a seasoned pro, it is a tool for every equestrian! With its user-friendly interface and informative genetic reports, Build-A-Horse makes understanding equine genetics a breeze, helping breeders of all levels refine their breeding strategies and elevate the quality of their breeding programs.

Build-A-Horse represents a paradigm shift in horse breeding, offering breeders and equine enthusiasts alike a powerful tool to unlock the full potential of a breeding program or to bring one amazing foal into the world. With its predictive capabilities and intuitive interface, Build-A-Horse enables anyone to make informed decisions that prioritize genetic integrity, health, and performance, ultimately contributing to the long-term sustainability and success of the equine industry.

Breeding for a Better Future

In the dynamic world of equine breeding, knowledge is power. By harnessing the advanced genetic testing solutions offered by Etalon Equine Genetics, horse breeders, owners, trainers, and enthusiasts can embark on their one-of-a-kind breeding journey with confidence, knowing they have the tools to produce healthier, more resilient foals. Whether you are a seasoned professional or a newcomer to the world of breeding, Etalon empowers you to breed better, one foal at a time.

Every foal represents the culmination of careful planning, dedication, and a commitment to excellence. With Etalon Equine Genetics by your side, the future of your breeding program is brighter than ever before. Start your journey towards breeding success today!

Ready to breed with science on your side? Create an Etalon account today to order testing and use Build-A-Horse!

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