Naked Foal Syndrome (NFS)
Naked Foal Syndrome (NFS)
Gene or region: ST14
Reference allele: G
Mutant allele: T
Affected Breeds: Akhal Teke
Research Confidence: Moderate confidence, strong correlation in larger studies
GG - n/n - negative for NFS
GT - nfs/n - "carrier" status - may pass NFS on to 50% of any offspring
TT - nfs/nfs - likely affected, likely lethal
What it does:
Naked Foal Syndrome (NFS) is a recessive genetic disorder resulting in the birth of foals with little to no hair and a general weakness with death occurring early in life (weeks to months).
Publications
A Nonsense Variant in the ST14 Gene in Akhal-Teke Horses with Naked Foal Syndrome
Anina Bauer, Theresa Hiemesch, Vidhya Jagannathan, Markus Neuditschko, Iris Bachmann, Stefan Rieder, Sofia Mikko, M Cecilia Penedo, Nadja Tarasova, Martina Vitková,
Nicolò Sirtori, Paola Roccabianca, Tosso Leeb, Monika M Welle
