Naked Foal Syndrome (NFS)

 

Gene or region:  ST14

Reference allele: G

Mutant allele: T

Affected Breeds: Akhal Teke

Research Confidence:                           Moderate confidence, strong correlation in larger studies

 

GG - n/n - negative for NFS 

 

GT - nfs/n - "carrier" status - may pass NFS on to 50% of any offspring

 

TT - nfs/nfs - likely affected, likely lethal

 

What it does:  

 

Naked Foal Syndrome (NFS) is a recessive genetic disorder resulting in the birth of foals with little to no hair and a general weakness with death occurring early in life (weeks to months). 

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Publications

 

A Nonsense Variant in the ST14 Gene in Akhal-Teke Horses with Naked Foal Syndrome 

Anina Bauer, Theresa Hiemesch, Vidhya Jagannathan, Markus Neuditschko, Iris Bachmann, Stefan Rieder, Sofia Mikko, M Cecilia Penedo, Nadja Tarasova, Martina Vitková, 

Nicolò Sirtori, Paola Roccabianca, Tosso Leeb, Monika M Welle