Equine Herpes Virus Type 1 (EHV-1) Induced Myeloencephalopathy (EHM) Risk


 

Equine Herpesvirus Myeloencephalopathy (EHM) risk

Gene or region: intron of TSPAN9

Reference allele: G

Mutant allele: A

Affected Breeds: Diverse breeds from the US, Canada and Europe

 

Research Confidence:  Discovery; findings require further validation.

What is Equine Herpes Virus Type 1(EHV-1)?

EHV-1 stands for Equine Herpes Virus type 1. Equine herpesviruses are DNA viruses that are found in horses all over the world, the majority of which will have no serious side effects. EHV-1 can cause four manifestations of disease in horses, including the neurological form, respiratory disease, abortion and neonatal death. 

What is Equine Herpesvirus Myeloencephalopathy (EHM)?

Equine Herpesvirus Myeloencephalopathy (EHM) is the neurologic disease associated with Equine Herpes Virus type 1 (EHV-1), representing one outcome of infection. This occurs to a subset of infected horses and its symptoms are painful and sometimes fatal. Neurologic signs result from inflammation of the blood vessels, blood clots, and death of neurologic tissue. EHM can affect one or multiple infected horses in a group.

What will my horse's results look like?

G/G or G/A
EHM Higher Risk - Two or one Equine Herpesvirus Myeloencephalopathy risk (EHMR) variants detected. Horse has 1.43x increased risk of developing the neurological form (Equine Herpesvirus Myeloencephalopathy, EHM) if infected by Equine Herpes Virus type 1 (EHV-1). 

 

A/A 

EHM Lower Risk - No Equine Herpesvirus Myeloencephalopathy risk (EHMR) variants detected. Horse has a lower risk of developing the neurological form (Equine Herpesvirus Myeloencephalopathy, EHM) if infected by Equine Herpes Virus type 1 (EHV-1).

 

What are some of the signs of EHV-1?

After infection, the incubation period is typically 4-6 days, but may be as short as 24 hours. EHV-1 typically causes a two-phase fever peaking on day 1 or 2 and again on day 6 or 7. Respiratory infections often present nasal and ocular discharge, and minimal coughing. There may also be some persistent enlargement of lymph nodes under the jaw. The neurologic form of EHV-1 (EHM) presents with minimal respiratory signs, and fever (rectal temperature greater than 101.5 degrees F) is considered a warning sign. Sudden neurologic disease progresses rapidly and reaches peak intensity within 24 to 48 hours from onset of initial neurologic signs. Horses may develop EHM even without any preceding fever and/or respiratory signs. Clinical signs of EHM may include:

  • Incoordination

  • Hind limb weakness

  • Loss of tail tone

  • Lethargy

  • Urine dribbling

  • Head tilt

  • Leaning against a fence or wall to maintain balance

  • Inability to rise

How does EHV-1 spread?

EHV-1 is contagious and spread by direct horse-to-horse contact via the respiratory tract through nasal secretions. It is important to know that this virus can also be spread indirectly through contact with physical objects that are contaminated with the virus, including but not limited to: human contaminated hands or clothing, contaminated equipment and tack, contaminated trailers used for transporting horses, contaminated wipe rags or other grooming equipment, or contaminated feed and water buckets. The air around the horse that is shedding the virus can also be contaminated. Although it is known that the virus can be airborne, it is difficult to establish the spread distance under typical horse management and environmental conditions.

 

What does this variant correlate to?
A genome-wide association study (GWAS) investigated host genetic variations associated with EHM, resulting in a variant (BIEC2_946397) within an intron of the tetraspanin 9 (TSPAN9) gene, which is expressed in endothelial cells and platelets, correlated with a recessive protective effect against EHM in EHV-1 affected individuals. Understanding the contribution of host genetic variation to the development of EHM can help with strategies for treating individual cases and managing outbreaks.

 

  

References:

 

Brosnahan, M. M., Al Abri, M. A., Brooks, S. A., Antczak, D. F., & Osterrieder, N. (2019). Genome-wide association study of equine herpesvirus type 1-induced myeloencephalopathy identifies a significant single nucleotide polymorphism in a platelet-related gene. The Veterinary Journal, 245, 49-54. https://doi.org/10.1016/j.tvjl.2018.12.013